Caffeine seems to be a complexed neurological substance
-
Acavia
- Posts: 698
- Joined: 4 years ago
I have been drinking coffee only last few years. While it stimulates me; it also calms me to an extent. It stimulates one by blocking the uptake of adenosine, but from what I have read it also manages dopamine, making dopamine stay in our nervous system longer, and also manages gaba which might have a calming effect similar to valium. Any doctors here who would give opinions on this:
https://www.ncbi.nlm.nih.gov/pmc/articl ... %20effects.
Evidence demonstrates that chronic caffeine exposure, primarily through consumption of coffee or tea, leads to increased alertness and anxiety. Preclinical and clinical studies showed that caffeine induced beneficial effects on mood and cognition. Other studies using molecular techniques have reported that caffeine exhibited neuroprotective effects in animal models by protecting dopaminergic neurons. Moreover, caffeine interacts with dopaminergic system, which leads to improvements in neurobehavioral measures in animal models of depression or attention deficit hyperactivity disorder (ADHD). Glutamatergic receptors have been found to be involved on the neurobiological effects of caffeine. Additionally, caffeine has been found to suppress the inhibitory (GABAergic) activity and modulate GABA receptors. Studies have also found that modulating these neurotransmitters leads to neurobehavioral effects. The linkage between the modulatory role of caffeine on neurotransmitters and neurobehavioral effects has not been fully discussed. The purpose of this review is to discuss in detail the role of neurotransmitters in the effects of caffeine on neurobehavioral disorders.
https://www.ncbi.nlm.nih.gov/pmc/articl ... %20effects.
Evidence demonstrates that chronic caffeine exposure, primarily through consumption of coffee or tea, leads to increased alertness and anxiety. Preclinical and clinical studies showed that caffeine induced beneficial effects on mood and cognition. Other studies using molecular techniques have reported that caffeine exhibited neuroprotective effects in animal models by protecting dopaminergic neurons. Moreover, caffeine interacts with dopaminergic system, which leads to improvements in neurobehavioral measures in animal models of depression or attention deficit hyperactivity disorder (ADHD). Glutamatergic receptors have been found to be involved on the neurobiological effects of caffeine. Additionally, caffeine has been found to suppress the inhibitory (GABAergic) activity and modulate GABA receptors. Studies have also found that modulating these neurotransmitters leads to neurobehavioral effects. The linkage between the modulatory role of caffeine on neurotransmitters and neurobehavioral effects has not been fully discussed. The purpose of this review is to discuss in detail the role of neurotransmitters in the effects of caffeine on neurobehavioral disorders.
-
Pressino
- Supporter ♡
- Posts: 1390
- Joined: 3 years ago
The article is an interesting and useful summary of recent research into the affects of caffeine on brain neurotransmitter activity in non-human (mostly mouse and rat) brains. Most of the author's speculation (i.e. hypotheses) about the potential risks and benefits of caffeine consumption in humans is based on plausible mechanisms, assuming of course that these mechanisms that were mostly demonstrated in genetically modified rodents apply to humans. There have been some human studies, mainly retrospective historical and survey based prospective studies on the relationship between caffeine consumption and whether or not certain human health problems occur.
I noted the following statement: "Recent evidence demonstrates that caffeine addiction is becoming popular worldwide [emphasis added]." This is the kind of thing that I see in quite a few medical articles written by foreign authors who are not native English speakers who would greatly benefit from proofreaders who are.
I noted the following statement: "Recent evidence demonstrates that caffeine addiction is becoming popular worldwide [emphasis added]." This is the kind of thing that I see in quite a few medical articles written by foreign authors who are not native English speakers who would greatly benefit from proofreaders who are.
