I've run in to these kinds of problems before too, where because of some difference in your setup or what coffee you're using there aren't good recommendations to get in to the ballpark when trying out a new blend. Here's what I try to do to get dialed in when I don't have anywhere to start from:
1. Use a good middle dose for the machine & basket, whatever will leave some headspace, but not too much. If nothing else this seems to reduce the chance of channeling or spritzers for me.
2. Adjust the grind to get a good flow. A bottomless PF is very useful here, but even with spouts it should be clear when the shot is pulling nicely, and when something's gone wrong. Don't worry about volume, I'd rather have a little bit of good espresso then a lot of mediocre espresso. Plus some blends will produce lots or very little crema, and it can make it very difficult to judge how much espresso you're actually getting.
3. Make adjustments for taste. I'm no expert here, and trying to figure out what combination of grind and dose changes to make can be tough. But trial and error always seems to work eventually

Taking notes is definitely a good idea, I keep a notebook by the machine, and try to use it at least every time I try a new blend. At this point the best advice I could give myself would be to "try more espressos and take more notes."
4. When I'm really stuck, I like to try 3 samples from the shot as it's pouring (just pull in to the drip tray, and grab little spoonfuls), from the beginning, middle and end (or split the shot up in to three cups for a more leisurely experience). It's amazing how different the espresso can taste from different times during the pour. I find this helps me identify the good flavors I'm trying to emphasize and figure out where any off flavors are coming from. Again, this is something I should do more often, instead of just trying it out when I'm completely lost it's probably something that would help me turn more good shots in to great shots.
5. If nothing else is working, clean everything, the grinder, the baskets, the machine. Break out the brushes and Joe Glo and go to town. I've definitely had a little gunk or residue somewhere screw up a whole morning's worth of shots before.
Good luck!