It depends on many factors. If the grinder retains a lot and the group is not clean, then the first shot is probably going to suffer. Of course, if the machine is never cleaned and the coffee is months old, the first shot is fine.
A short sacrificial grind may not clear the grinder sufficiently. Lately, I've been experimenting with updosing the first shot about 0.3g on a 10g single to maintain the pour. If I dose 10g, the first shot runs a bit fast. Even with the same pour, shots 2+ seem more balanced.
Over the years I've experimented with knocking the puck and flushing / back flushing the group immediately after the shot and leaving the puck in the group until the next shot, pulling a short flow before knocking the puck. IMO, leaving the puck is preferable. It could be genetic. I like Yorkshire Bitter, dark chocolate, Lagavulin and rarely order dessert.
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Sink that First Shot