Unfortunately, there is a dark side to dosing the grinder on a per shot basis. The grind setting must be adjusted, not just a little bit, but a huge amount. JonR reports a grind setting that is 9-10 ticks finer on his Robur. I only need 7-8 ticks finer on mine, but that's still more than the entire espresso range with a bean load, regardless of type of coffee, roast degree, or age. When the grind setting changes so profoundly, it's a foregone conclusion that the particle size distribution is significantly altered. I'm convinced this is tasteable in the cup, although it's certainly possible that blind taste tests* will prove me wrong.
The finer grind setting is not the only thing that will affect the particle size distribution. As the bean load goes from 15-20g (for a double shot) down to 0g during the grinding process, the first few grams will be ground more finely and the last few grams more coarsely. This implies that the range of particle sizes will be greater for single shot dosing. Assuming that grinder manufacturers know a thing or two about grinder design, and commercial grinders were never designed for a per-shot dosing usage pattern, this is probably not a Good Thing.
One technique that may help: start the grinder running, and gradually trickle the beans into the hopper, at about the same rate they are ground. At least the bean load will remain constant throughout the grinding process. You will need to set the grind adjustment even finer (just a couple of ticks on my Robur), and of course be prepared for increased popcorning while grinding the first part of the shot.
Again, I'm not advocating single shot dosing and grinding. But this approach seems more logical than dumping in one shot worth of beans and hitting the grind switch.
* which I am, fortunately, unable to perform in my kitchen



