After the burrs are cleaned, around 5 grams of coffee will get compacted on the sweeper vanes in the grind chamber. Once this has happened, the weight of coffee going in, will on average equal the coffee coming out (how can it not?). I do not know whether the compacted coffee stays where it is, or if it exchanges mass with the coffee being ground. My sense is that there is very little exchange.
In addition to the compacted grounds, there is around 2 to 4 grams of loose grinds in the grind chamber and the deep recesses of the chute. The amount of this depends on the size of the grind chamber and burrs. It is worst for the conical grinders, since the 63 to 71mm burrs are housed in grind chambers also designed for larger 80 to 85mm flat burrs. The extra space fills with loose grinds.
If you have a full hopper, you will always get this loose coffee in your next shot. If you spoon the coffee into the throat, running on empty and several times will get the bulk of this out in the round in which it is ground.
If you weigh the coffee going in, you will usually get around +/- 1/2 gram variances in the final weight. Occasionally it can get worse, but I figure the +/- 1/2 grams is right 9 out of 10 times. If you are short in one grind, you will be long the next time -- there is obviously a serial correlation, since the amount coming out has to be the same in the long run as the amount going in.
My opinion on dose is the same as it is for temperature, pressure, and all the other stuff: close is good enough; don't waste your time and effort on getting it perfect; focus on the coffee instead.
Of course, if you really know for certain that 9.1 bar is better than 9.2, 201F better than 202, and 14.5 grams better than 15, go for it




